Home  Research  Education  Publications  Events  Organization  People  News
People
 
Kamran Ikram


 47 

Contact

Kamran Ikram

Phone010-7044189
Emailm.ikram@erasmusmc.nl or *30848

Biographical Sketch

POSITION TITLE: Associate Professor in Neurology and Epidemiology


EDUCATION/TRAINING

Institution and location Degree Completion Date Field of Study
Netherlands Institute for Health Sciences, the Netherlands MSc 09/1999 Clinical Epidemiology
Erasmus University Medical Center, Rotterdam, the Netherlands MD 09/2001 Medicine
Erasmus University Medical Center, Rotterdam, The Netherlands PhD 09/2005 Epidemiology
Erasmus University Medical Center, Rotterdam, The Netherlands Neurologist 11/2010 Neurology

Personal Statement

I am currently an Associate Professor at the Departments of Neurology and Epidemiology, Erasmus Medical Center Rotterdam, The Netherlands and a visiting Associate Professor at the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, USA.

 

After completing my dual training in Epidemiology (PhD 2005) and Neurology (Dutch Specialist Board Certified 2010) at the Erasmus Medical Center Rotterdam, the Netherlands, I moved to Singapore. Initially I worked as a Postdoc at the National University of Singapore and subsequently between 2013-2014 as Assistant Professor and between 2014-2015 as Associate Professor. During the period 2011-2015 I was Principal Investigator of the Epidemiology of Dementia (EDIS) Study and was involved in several studies using retinal and neuro-imaging to study cerebrovascular pathology. My research has shown: (a) “Proof-of-concept” that microvascular parameters obtained from fundus photographs provide additional information on the status of the cerebral microvasculature beyond conventional MRI; (b) Besides arteriolar changes, venular changes in the retina have shown consistent associations with both subclinical and clinical vascular pathology in the brain; (c) Important interactions between cerebrovascular (as reflected by retinal vascular imaging) and neuro-degenerative (as visualized by Optical Coherence Tomography) processes in the brain. After returning to the Netherlands in 2015, I joined the Department of Neurology, Rudolf Magnus Brain Center, UMC Utrecht and continued my research as a collaboration between UMC Utrecht and NUS with a focus on novel neuro-imaging markers of cerebrovascular pathology, including cortical microinfarcts. During this period, I got the opportunity to return to my alma mater Erasmus Medical Center in Rotterdam. Within the Rotterdam Study, I am leading the work on the epidemiology of clinical cerebrovascular diseases. I have published >160 peer-reviewed scientific papers (H-index = 25).

Positions and Honors

Positions and employment:

09/2016-present: Associate Professor, Departments of Neurology & Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

05/2016-present: Visiting Associate Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA

11/2005-08/2016: Neurologist, Department of Neurology, Rudolf Magnus Brain Center, UMC Utrecht, the Netherlands

03/2014-11/2015: Associate Professor on Tenure Track, Duke-NUS Medical School, National University of Singapore

06/2013-02/2014: Assistant Professor on Tenure Track, National University of Singapore

01/2011-05/2013: Lee Kuan Yew Postdoctoral Fellow, National University of Singapore

12/2005-11/2010: Residency training in Neurology, Department of Neurology, Erasmus MC, Rotterdam, the Netherlands

09/2001-08/2005: PhD student, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

 

Honors:

2013: Outstanding Young Researcher Award awarded by Singapore Eye Research Institute

2012: National Medical Research Council’s Clinician Scientist Award, Singapore

2012: Young Investigator Award by the Asian Pacific Society of Hypertension

2011: Lee Kuan Yew Postdoctoral Fellowship Award, Singapore

2007: P.G. Binkhorst Award from “Nederlands Oogheelkundig Gezelschap” (Dutch Ophthalmological Society) for the best PhD-thesis 2006-2007

Contributions to Science

1. Conventional MRI markers of cerebrovascular pathology, including infarcts, white matter hyperintensities (WMH), and cerebral microbleeds - though highly prevalent in elderly populations - do not fully encompass the burden of vascular brain pathology. In recent years, cortical cerebral microinfarcts have been proposed as a novel markers of cerebrovascular pathology both in autopsy and neuro-imaging studies (including 7T and 3T MRI scans). In 2015 and 2016 we published two papers showing a clear link between this novel marker of cerebrovascular pathology and cognitive impairment and dementia. In the first paper we showed this link among memory-clinic patients and in the second paper among a relatively healthy population drawn from a population-based study from Singapore. These studies provide further evidence that vascular brain pathology and neurodegeneration are strongly interlinked.

Relevant papers:

  1. S.J. van Veluw, S. Hilal, H.J. Kuijf, M.K. Ikram, X. Xin, T.B. Yeow, N. Venketasubramanian, G.J. Biessels, C. Chen. Cortical microinfarcts on 3T MRI: clinical correlates in memory-clinic patients. Alzheimer’s & Dement 2015; 11: 1500-1509
  2. S. Hilal, E. Sikking, M.A. Shaik, Q.L. Chan, S.J. van Veluw, H. Vrooman, C.Y. Cheng, C. Sabanayagam, C.Y. Cheung, T.Y. Wong, N. Venketasubramanian, G.J. Biessels, C. Chen, M.K. Ikram. Cortical cerebral microinfarcts on 3 Tesla magnetic resonance imaging: a novel marker of cerebrovascular disease. Neurology in press 2016

 

2. Over the last decade my research has shown “proof-of-concept” that microvascular parameters obtained from fundus photographs provide additional information on the status of the cerebral microvasculature beyond conventional MRI.

  1. U. Mutlu, L.G.M. Cremers, M. de Groot, A. Hofman, W.J. Niessen, A. van der Lugt, C.C.W. Klaver, M.A. Ikram, M.W. Vernooij, M.K. Ikram. Retinal microvasculature and white matter microstructural integrity: the Rotterdam Study. Neurology Epub ahead of print 2016
  2. C.Y.L. Cheung, Y.T. Ong, M.K. Ikram, C. Chen, T.Y. Wong. Retinal microvasculature in Alzheimer’s disease. J Alzheimers Dis 2014; 42 Suppl 4: S339-S352
  3. M.K. Ikram, C.Y.L. Cheung, T.Y. Wong, C.P.L.H. Chen. Retinal pathology as biomarker for cognitive impairment and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2012; 83: 917-922

 

3. Over the last few decades, research has mainly focused on the arterial system, whereas the venous system has received less attention, partly due to the relative difficulty in visualizing the cerebral venous system. In recent years, there is an increasing body of evidence, including retinal imaging, showing that the venous system may also play an important role in cerebrovascular and neurodegenerative diseases. In 2004, I published the first report indicating that – besides arteriolar calibers - venular calibers in the retina are also related to cardiovascular risk factors. Subsequently, a consistent body of evidence has emerged showing a clear link between venular parameters and cardiovascular and cerebrovascular diseases.

  1. M.K. Ikram, F.J. de Jong, J.R. Vingerling, J.C.M. Witteman, A. Hofman, M.M.B. Breteler, P.T.V.M. de Jong. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci 2004; 45: 2129-2134
  2. M.K. Ikram, F.J. de Jong, E.J. van Dijk, N.D. Prins, A. Hofman, M.M.B. Breteler, P.T.V.M. de Jong. Retinal vessel diameters and cerebral small vessel disease: The Rotterdam Scan Study. Brain 2006; 129: 182-188
  3. M.K. Ikram, J.A.M.J.L. Janssen, A.M.E. Roos, I. Rietveld, J.C.M. Witteman, M.M.B. Breteler, A. Hofman, C.M.van Duijn, P.T.V.M. de Jong. Retinal vessel diameters and risk of diabetes mellitus: The Rotterdam Study. Diabetes 2006; 55: 506-510
  4. Y.T. Ong, D.A. de Silva, C.Y. Cheung, H.-M. Chang, F.-P. Woon, C. Chen, M.-C. Wong, T.Y. Wong, M.K. Ikram. Microvascular structure and network in the retina of patients with stroke. Stroke 2013; 44: 2121-2127
  5. C.Y. Cheung, Y.T. Ong, M.K. Ikram, S.Y. Ong, X. Li, S. Hilal, J.A. Catindig, N. Venketasubramanian, P. Yap, D. Seow, C.P. Chen*, T.Y. Wong*. Microvascular structure and network in the retina in patients with Alzheimer’s disease. Alzheimer’s Dement 2014; 10: 135-142

Research Support

2016-2017:      Role: Principal investigator from the Rotterdam Study [€95,000], multi-center project

                        European Institute of Innovation and Technology – EIT Health

                        Project: “Multimodal strategies to promote a healthy brain in aging: Innovative evidence-based tools (MULTI-MODE).

 

2013-2016:      Role: Principal Investigator (Theme 5: Epidemiology of Dementia in Singapore (EDIS) Study) & Co-Investigator Memory

                        Aging & Cognition Centre (MACC) [S$3,200,000]

                        National Medical Research Council, Singapore

                        Part of the project application: Metabolic Medicine, Infectious Diseases, Neuroscience Enablers (MINE).

 

2013-2015:      Role: Mentor to Dr. Gavin Tan, PhD student [S$150,000]

                        SingHealth Foundation Research Grant – Transition Project Grant, Singapore

                        Project: “Novel biomarkers for diabetic retinopathy”

 

2012-2014:      Role: Principal investigator [S$150,000]

                        National University Health System (NUHS) – Harvard Medical School Beth Israel Deaconess Medical Center (BIDMC) Seed

                        Fund Grant Project: “Novel retinal vascular imaging and biochemical biomarkers for stroke: the Cardiovascular Health Study”

 

2012-2015:      Role: Principal Investigator [S$675,000]

                        National Clinician Scientist Award, Investigator Category, Singapore

                        Project: “Retinal vascular imaging study in Transient Ischemic Attacks (REVISTA)”

 

2012-2013:      Role: Principal Investigator [S$95,000]

                        NUHS Clinician Scientist Program Grant, Singapore

                        Project: “Novel eye imaging for brain diseases in the elderly”

 

2012-2014:      Role: Principal Investigator [S$179,500]

                        FY2011 Academic Research Fund (MOE AcRF Tier 1 FRC Grant), Singapore

                        Project: “Novel eye biomarkers for degenerative and vascular brain diseases”

 

2011-2012:      Role: Principal Investigator [S$600,000]

                        Lee Kuan Yew Postdoctoral Fellowship Grant, Singapore

                        Project: “Novel eye biomarkers for degenerative and vascular brain diseases” 

 

2011-2014:      Role: Principal Investigator [€250,000]

                        VENI Grant awarded by the “Netherlands Organization for Scientific Research”

                        Project: “The influence of the microcirculation on the cardiovascular development in young children: the Generation R”      

 

2010-2012:      Role: Principal Investigator [€30,000]

                        Grant from “Prof.dr. Henkes Stichting”, the Netherlands for international clinical research fellowship

 

2009-2010:      Role: Principal Investigator [€35,000]

                        Grant from “Prof.dr. Henkes Stichting”, the Netherlands for post-doc research

                        Project: “Genome-wide association studies on retinal vascular abnormalities”

 
 
Disclaimer  |  Copyrights  |  Mission  |  Privacy  |  E-mail