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Albert Hofman, MD PhD


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Albert Hofman, MD PhD

Phone+31 (0)10 70 43488
Emaila.hofman@erasmusmc.nl

Biographical Sketch

Albert Hofman received an MD in 1976 from the University of Groningen, and a PhD in 1983 from the Erasmus University Rotterdam. He was appointed in 1981 as an Assistant Professor at the Erasmus University Medical School and was promoted to Associate Professor in 1984. Since 1988 he has been full Professor and Chair in the Department of Epidemiology at the Erasmus Medical Center. In addition, Albert Hofman has been a Science Director at the Netherlands Institute for Health Sciences since 1992, as well as an adjunct Professor of Epidemiology at the Harvard School of Public Health since 1998, and a Visiting Professor of Clinical Epidemiology since January 2016. Dr. Hofman has an excellent record of teaching, including being the initiator and program director of the Erasmus Summer Program since 1991, and teaching the summer session courses on Fundamentals of Epidemiology and on Study Design in Clinical Epidemiology at Harvard.

 

Per 1 July 2016 Albert Hofman has stepped down as Chair of the Department of Epidemiology at the Erasmus Medical Center and as Science Director at the Netherlands Institute for Health Sciences. Per that date he has been named the Stephen B. Kay Family Professor of Public Health and Clinical Epidemiology and Chair of the Department of Epidemiology at Harvard.

Contributions to Science

 

Solouki AM, Verhoeven VJ, van Duijn CM, Verkerk AJ, Ikram MK, Hysi PG, Despriet DD, van Koolwijk LM, Ho L, Ramdas WD, Czudowska M, Kuijpers RW, Amin N, Struchalin M, Aulchenko YS, van Rij G, Riemslag FC, Young TL, Mackey DA, Spector TD, Gorgels TG, Willemse-Assink JJ, Isaacs A, Kramer R, Swagemakers SM, Bergen AA, van Oosterhout AA, Oostra BA, Rivadeneira F, Uitterlinden AG, Hofman A, de Jong PT, Hammond CJ, Vingerling JR, Klaver CC. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet. 2010; 42:897-901.

Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT Jr, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T, Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K, Hofman A, , Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM; CHARGE Consortium; GERAD1 Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010; 303:1832-40

Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010; 376:180-8.

Lp-PLA(2) Studies Collaboration, Thompson A, Gao P, Orfei L, Watson S, Di Angelantonio E, Kaptoge S, Ballantyne C, Cannon CP, Criqui M, Cushman M, Hofman A, , Packard C, Thompson SG, Collins R, Danesh J. Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet 2010; 375:1536-44

Mook-Kanamori DO, Steegers EA, Eilers PH, Raat H, Hofman A, Jaddoe VW.Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA 2010; 303:527-34.

Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K, Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, van Duijn CM, Breteler MM, Longstreth WT Jr, Wolf PA. Genomewide association studies of stroke. N Engl J Med. 2009; 360:1718-28.

Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.Lancet 2008; 372:1953-61.

Vernooij MW, Ikram MA, Tanghe HL, Vincent AJPE, Hofman A, Krestin GP, Niessen WJ, Breteler MMB, Van der Lugt A. Incidental findings on brain MRI in the general population. N Engl J Med 2007;357:1821-85.

Bos MJ, Van Rijn MJE, Witteman JCM, Hofman A, Koudstaal PJ, Breteler MMB. Incidence and prognosis of transient neurological attacks. JAMA 2007;298:2877-85.

van Oijen M, Jan de Jong F, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Atherosclerosis and risk for dementia. Ann Neurol. 2007.

Bos MJ, Schipper CM, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM. High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam Study. Circulation. 2006;114:1591-8..

Despriet DD, Klaver CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, Boekhoorn SS, Vingerling JR, Hofman A, Oostra BA, Uitterlinden AG, Stijnen T, van Duijn CM, de Jong PT.Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA. 2006;296:301-9.

Hofman A, de Jong PT, van Duijn CM, Breteler MM. Epidemiology of neurological diseases in elderly people: what did we learn from the Rotterdam Study? Lancet Neurol. 2006;5:545-50.

Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113:657-63.

van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM. C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study. Circulation. 2005;112:900-5

Vliegenthart R, Oudkerk M, Hofman A, Oei HH, van Dijck W, van Rooij FJ, Witteman JC. Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation. 2005;112:572-7.

Oei HH, van der Meer IM, Hofman A, Koudstaal PJ, Stijnen T, Breteler MM, Witteman JC. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Circulation. 2005;111:570-5.

Meurs JB van, Dhonukshe-Rutten RA, Pluijm SM, Klift M van der, Jonge R de, Lindemans J, Groot LC de, Hofman A, Witteman JC, Leeuwen JP van, Breteler MM, Lips P, Pols HA, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350:2033-41.

Schuit SC, Oei HHS, Witteman JCM, Geurt van Kessel CH, Meurs JBJ van, Nijhuis RL, Leeuwen JPTM van, Jong FH de, Zillekens MC, Hofman A, Pols HAP, Uitterlinden AG. Estrogen receptor α gene polymorphisms and risk of myocardial infarction. JAMA 2004;291:2969-71.

Tiemeier H, Dijck W van, Hofman A, Witteman JCM, Stijnen T, Breteler MMB. Relationship between atherosclerosis and late-life depression. The Rotterdam Study. Arch Gen Psychiatry 2004;61:369-76.

Meer IM van der, Bots ML, Hofman A, del Sol AI, Kuip DA van der, Witteman JC. Predictive value of non-invasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 2004;109:1089-94.

Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348:1215-22.

Geerlings MI, Launer LJ, de Jong FH, Ruitenberg A, Stijnen T, van Swieten JC, Hofman A, Witteman JC, Pols HA, Breteler MM. Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Ann Neurol 2003;53:607-15.

Croes EA, Dermaut B, Houwing-Duistermaat JJ, Van den Broeck M, Cruts M, Breteler MM, Hofman A, van Broeckhoven C, van Duijn CM. Early cognitive decline is associated with prion protein codon 129 polymorphism. Ann Neurol 2003;54:275-6.

Schoofs MW, van der Klift M, Hofman A, de Laet CE, Herings RM, Stijnen T, Pols HA, Stricker BH. Thiazide diuretics and the risk for hip fracture. Ann Intern Med 2003;139:476-82.

Leeuwen R van, Vingerling JR, Hofman A, Jong PT de, Stricker BH. Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement. BMJ 2003;326:255-6.

Hollander M, Bots ML, Iglesias del Sol A, Koudstaal PJ, Witteman JCM, Grobbee DE, Hofman A, Breteler MMB. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asympotomatic elderly: the Rotterdam Study. Circulation 2002;105:2872-7.

Engelhart MJ, Geerlings MI, Ruitenberg A, Swieten JC van, Hofman A, Witteman JCM, Breteler MMB. Dietary intake of antioxidants and risk of Alzheimer’s disease: the Rotterdam Study. JAMA 2002;287:3223-9.

Ruitenberg A, Swieten JC van, Witteman JCM, Mehta KM, Duijn CM van, Hofman A, Breteler MMB. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet 2002;359:281-6.

Veld BA in 't, Ruitenberg A, Hofman A, Launer LJ, Duijn CM van, Stijnen T, Breteler MMB, Stricker BHC. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.

N Engl J Med 2001;345:1515-21.

Groot JC de, Leeuw F-E de, Oudkerk M, Gijn J van, Hofman A, Joiles J,Breteler MMB. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol 2000;47:145-51.

Salas M, Hofman A, Stricker BHCh. Confounding by indication: an example of variation in the use of epidemiologic terminology. Am J Epidemiol 1999;149:981-3.

Witteman JCM, D'Agostino RB, Stijnen Th, Kannel WB, Cobb JC, Ridder MAJ de, Hofman A, Robins JM. G-estimation of causal effects: isolated systolic hypertension and cardiovascular death in the Framingham Heart Study. Am J Epidemiol 1998;148:390-401.

Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FEA, Grant SFA, Hofman A, Leeuwen JPTM van, Pols HAP, Ralston SH. Relation of alleles of the collagen type 11 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 1998;338:1016-21.

Ott A, Slooter AJC, Hofman A, Harskamp F van, Witteman JCM,Broeckhoven C Van, Duijn CM van, Breteler MMB. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet 1998;351:1840-3.

Duijn CM van, Delasnerie-Lauprêtre N, Masullo C, Zerr I, Silva R de, Wientjes DPWM, Brandel J-P, Weber T, Bonavita V, Zeidler M, Alpérovitch A, Poser S, Granieri E,Hofman A, Will RG, for the European Union (EU) Collaborative Study Group of Creutzfeldt-Jakob disease (CJD). Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95. Lancet 1998;351:1081-5.

Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, Harskamp F van, Duijn CM van, Broeckhoven C van, Grobbee DE. Atherosclerosis, apolipoprotein and prevalence of dementia and Alzheimer's disease. The Rotterdam Study. Lancet 1997;349:151-4.

Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alprovitch A, Poser S, Pocchari M, Hofman A, Smith PG. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996;347:921-5.

Hoes AW, Grobbee DE, Lubsen J, Man in t Veld AJ, Does E van der, Hofman A. Diuretics, -blockers, and the risk for sudden cardiac death in hypertensive patients. Ann Intern Med 1995;123:481-7.

Duijn CM van, Knijff P de, Cruts M, Wehnert A, Havekes LM, Hofman A, Broeckhoven C van. Apolipoprotein E4 allele in a population based study of early onset Alzheimer's disease. Nature Genet 1994;7:74-9.

ASPECT Research Group. The effect of long-term anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction. Lancet 1994;343:499-504.

Witteman JCM, Grobbee DE, Valkenburg HA, Hemert van AM, Stijnen T, Hofman A. Cigarette smoking and the development and progression of aortic atherosclerosis; A 9 year population-based follow-up study in women. Circulation 1993;88:2156-62.

Bots ML, Swieten JC van, Breteler MMB, Jong PTVM de, Gijn J van, Hofman A, Grobbee DE. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet 1993;341:1232-7.

Hendriks L, Duijn CM van, Cras P, Cruts M, Hul W van, Harskamp van F, Warren A, Innis Mc MG, Antonara SE, Martin JJ, Hofman A, Broeckhoven C van. Presenile-dementia and cerebral-hemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene. Nature Genet 1992;1:218-21.

Hooft IMS van,Grobbee DE,Derkx FHM, Leeuw PW de,Schalekamp MADH,Hofman A. Renal hemodynamics and the renin-angiotensin-aldosterone system in the early phase of primary hypertension. N Engl J Med 1991;324:1305-11.

Hofman A, Grobbee DE, Jong PTVM de, Ouweland FA van den. Determinants of disease and disability in the elderly: the Rotterdam Study. Eur J Epidemiol 1991;7:403-22.

Bruining GJ, Grobbee DE, Scheffer GJ, Bruijn AM de, Molenaar JL, Hofman A, Bruining HA, Valkenburg HA. Ten-year follow-up study of islet-cell antibodies and childhood diabetes mellitus. Lancet 1989;i:1100-3.

Walter HJ, Hofman A, Vaughan RD, Wynder E. Modification of risk factors for coronary heart disease. Five-year results of a school-based intervention trial. N Engl J Med 1988;318:1093-100.

Grobbee DE, Hofman A. Calcium supplementation lowers diastolic blood pressure in young people with mild hypertension. Lancet 1986;2:703-7.

Hofman A, Valkenburg HA. Determinants of change in blood pressure during childhood. Am J Epidemiol 1983;117:735-43.

Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA 1983;250:370-3.

 

 
 
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