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André Uitterlinden


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André Uitterlinden

Phone+31 (0)10 70 43573
Emaila.g.uitterlinden@erasmusmc.nl

Biographical Sketch

POSITION TITLE: Professor of Complex Genetics


EDUCATION/TRAINING

Institution and location Degree Completion Date Field of Study
Leiden University BSc 1984 Molecular Genetics
Leiden University PhD 1993 Molecular Genetics

Personal Statement

André Uitterlinden is Professor of Complex Genetics at Erasmus University Medical Center (EMC) in Rotterdam where he is holding positions in 3 departments: Internal Medicine, Epidemiology and Clinical Chemistry. His research is focusing on identification and characterization of genetic factors for common traits and diseases including anthropometry, endocrine traits and disorders, and locomotor diseases such as osteoporosis and osteoarthritis. At the Erasmus MC he is also head of one of Europe’s largest high-throughput DNA facilities, the Human Genotyping Facility Huge-F* which provides services for DNA isolation, genotyping and sequencing. He is coordinating all molecular genetic analyses in 2 major cohort studies: the Rotterdam Study (15,000 elderly subjects) and the Generation R birth-cohort (7,000 children + 12,000 parents), including the Genome Wide Association Study (GWAS) of both study cohorts. He is collaborating with many (large) international epidemiological study populations and coordinating the Genetic Factors for Osteoporosis (GEFOS) consortium involving >150.000 subjects to identify genetic risk factors for osteoporosis. He is a member of the Research Steering Committee of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and has been director of the Netherlands Consortium for Healthy Aging (NCHA, 2008-2014, € 30 mio). André Uitterlinden has published over 1000 scientific papers in refereed journals (H-index 106, August 2016) and he is listed in the Thomson Reuters’ list of Most Cited Researchers. Currently he is head of the genetic lab research group in the Erasmus MC in which he supervises 9 PhD students. Under his supervision 88 PhD students have reached their doctoral degree during the last 16 years.  In the educational field within the Erasmus MC he is organising annual international courses on complex genetics which are very well attended.

 

* Highlights of Huge-F (2000 onwards):

  • GWAS of Rotterdam Study (n=12000) and GenR (n=6000)
  • BBMRI exome chip, RNA sequencing, methylation chip for major Dutch biobanks (n=6000 - 35000)
  • WES of Rotterdam Study (n=2500)
  • Coordinator EU-GSA consortium (> 500K samples with GSA chip)

Positions and Honors

Positions and Employment:

1.         TNO Institute for Experimental Gerontology (TNO-IvEG; Rijswijk, The Netherlands)

            1984-1985: Research Associate working at Lifecodes, Corp. (Valhalla, New York, USA).

            1985-1988: Research Associate at TNO IvEG

            1988-1990: Head of the section Genome Analysis at TNO-IvEG

2.         INGENY B.V. (Leiden, The Netherlands)

            1990-1994: Head of the Department of Genetic Diagnostics

3.         Erasmus Medical Centre Rotterdam, Academic Hospital Dijkzigt Rotterdam

            1994-2000: Senior Research Fellow, Dept of Internal Medicine, Calcium, Bone and Metabolism lab

            1998                      Honorary position at Department of Epidemiology & Biostatistics as Senior Research Fellow

            2000                      Staff member Department of Internal Medicine (0.7 fte)

            2000                      Staff member Department of Clinical Chemistry (0.3 fte)

            2001                      Head of the Genetic Laboratory Internal Medicine

            2001                      Head of Human Genomics Facility

            2004                      Associate Professor (UHD)

            2007                      Full Professor Complex Genetics

 

Other Experience and Professional Memberships

1. Membership Erasmus MC committees:

             * Member of the Equipment-committee for the Biomics Core Facility (2001- onwards)

             * Member of the BioBank committee (2005- onwards)

             * Member of the Phamacogenetics committee (2006- onwards)

             * Member of the Mrace-subcommittee Equipment (2002- onwards)

             * Member of the Mrace General Assembly advising the dean (2009- onwards)

2. Board-membership Scientific Societies:

             * Member of the Board (treasurer) of the Dutch Society for Calcium and Bone Metabolism NVCB (2001-2005)

3.Editorial Board membership Journals

             * Calcified Tissue International (CTI; since 1999)

             * Human Genomics & Proteomics (since 2008)

             * Dutch Journal for Bone and Calcium Research (2003-2006)

             * Chief-Editor of the NTCB: Dutch Journal for Bone and Calcium Research (2006-2012)

             * European Journal of Clinical Investigation (EJCI; since 2009)

             * Journal of Clinical Endocrinology and Metabolism JCEM; since 2011)

             * Journal of Bone and Mineral Research (JBMR; since 2016)

4. Consultancies:

             * Consultant Dutch Forensic Laboratory, Rijswijk, The Netherlands, 1991-1992

             * Consultant Dutch Cattle Syndicate, Arnhem, The Netherlands 1992-1995

             * Consultant Celltech-Chiroscience Inc., Seattle, USA, 2001-2003

             * Occasional consulting for Organon, Roche, Illumina, Ely Lilly, MSD

5. Leaderships: Coordinator/Member Research Steering Committees :

            * Member of the FAMOS Research Steering Committee, Oxagen Ltd., (1999-2004)

            * Member of the SCA Research Steering Committee, Oxagen Ltd., (2001- 2004)

            * Member of the IMPACT Genotyping Steering Committee, Aventis Pharmaceuticals, (2002-2006)

            * Coordinator of the EU FP5 funded GENOMOS consortium (2003-2007)

            * Coordinator of the EU FP7 funded GEFOS consortium (2008-2014)

            * Member Research Steering Committee CHARGE consortium (2007 onwards)

            * Director Netherlands Consortium Healthy Ageing (NGI-NCHA) (2008-2014)

            * Coordinator GSA Consortium, Illumina array (2015 onwards)

Contributions to Science

I.    H-Index (Web of Science September 14th, 2016):             107

      The average impact factor of my (cited) publications is:       51,69

 

II.    My ten most contributing publications

1. Uitterlinden AG et al. Two-dimensional DNA fingerprinting of human individuals. Proc Natl Acad Sci USA 86:2742-2746 (1989, cited 64 times, WoS August 2016)

2. Muyzer G, de Waal E, Uitterlinden AG. Profiling of complex microbial populations by DGGE analysis of PCR amplified 16S rDNA. Appl Environ Microbiol 59:695-700 (1993, cited 7710 times, WoS August 2016)

3. Uitterlinden AG, et al. Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. New Engl J Med 338:1016-1021 (1998, cited 339 times, WoS August 2016)

4. van Meurs JBJ, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture. New Engl J Med

2004 May 13;350(20):2033-41 (2004, cited 392 times, Wos August 2016)

5. Rivadeneira F* et al. Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009, 41, 1199 – 1206 (2009, cited 335 times, WoS August 2016)

6. Lango Allen H*, Estrada K*, Lettre G*, Berndt SI*, Weedon MN*, Rivadeneira F*, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832-8

(2010, cited 516 times, WoS August 2016)

7. Stolk L* et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012;44(3):260-8 (2012, cited 100 times, WoS August 2016)

8. Zillikens MC, Uitterlinden AG et al. PLS3 Mutations in X-Linked Osteoporosis and Fractures, New England Journal of Medicine, 2013 Oct 17; 269(16) 1529-36 (2013, cited 28 times, WoS August 2016)

9.Rietveld CA et al. GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment, Science,  2013 Jun 21;340(6139):1467-71 (2013, cited 136 times, WoS August 2016)

10.Mayerle J et al.  Identification of Genetic Loci Associated with Heliobacter pylori Serologic Status, JAMA, 2013 May 8; 309(18):1912-20 (2013, cited 44 times, WoS August 2016)

 

III.  The top 3 leading Journals in my field are:

  1. Nature Genetics
  2. American Journal of Human Genetics
  3. Human Molecular Genetics

     

IV.  9 Patents

Research Support

Total research support received as per September 2016 ~42 million euros over the past 22 years.

André Uitterlinden is heading a human genotyping facility with a yearly turnover of ~5 million euros with a total turnover of ~ 42 million euro’s since 2006.

 

Research Support (2006 – onwards):

Completed:

1. “A Genome-wide Association database of the Rotterdam Study”, Coordinator, Principal Investigator, NWO, 2006-2012,€ 6.000.000,=

2. “GEFOS” (201865), Coordinator, EU-FP7, 2007-2013, € 3.000.000,=

3. “TREAT-OA” (200800), Participant, EU-FP7, 2007-2013, € 500.000,=

4. “Generation R GWAS”, Principal investigator, Erasmus MC, 2007- (dean; co-funded by several departments), € 2.500.000,=

5. “NGI-NCHA: Netherlands Consortium Healthy Aging”, Consortium Director, NWO-NGI, 2008-2014 (project nr. 050-060 810), € 13.500.000,=

6. “High Throughput Next Generation DNA sequencing”, Coordinator, Principal investigator Erasmus MC, 2007- (dean; co-funded by 2 depts),€1.800.000,=

Ongoing:

7.   “Genetic susceptibility viral pathogens”, Participant, NWO/NGI VIRGO, 2010-2016, € 350.000,=

8.    “Genetic susceptibility late effects of chemotherapy”, Participant, EU-FP7 PANCARE, (2013-2018), € 460.000,=

9.    “Genetic susceptibility microbial pathogens”, Participant, EU-FP7 TAILORED, 2013-2018, € 600.000,=

 

 
 
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