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Cornelia van Duijn, PhD


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Cornelia van Duijn, PhD

Phone+31 (0)10 70 43394 or +31 (0)10 70 38194
Emailc.vanduijn@erasmusmc.nl

Biographical Sketch

POSITION TITLE: Full professor Genetic Epidemiology, Erasmus MC / Full professor Translational Epidemiology, Leiden University

 


EDUCATION/TRAINING

 

Institution and location Degree Completion Date Field of Study
Agricultural University of Wageningen, The Netherlands MSc 1987 Human Nutrition
Erasmus University, Rotterdam, The Netherlands PhD 1991 Genetic Epidemiology
Boston University, USA Postdoc 1991 - 1992 Genetic Epidemiology
Erasmus University, Rotterdam, The Netherlands Full professor 2001 - Genetic Epidemiology
Leiden University Full professor 2016 - Faculty Science

 

Personal Statement

Cornelia van Duijn is a professor of Genetic Epidemiology at the Department of Epidemiology of the Erasmus University Medical Center. Cornelia van Duijn is involved as a principle investigator in three large-scale population- and family-based studies: the Erasmus Rucphen Family (ERF) study, the Rotterdam study and Generation R. Her work focuses on –omics research in neurodegenerative disorders including Alzheimer's disease, Parkinson’s disease, Creutzfeldt–Jakob disease and open angle glaucoma. She is a leader in several international genome wide association consortia including CHARGE (Cohorts for Heart & Aging Research in Genome Epidemiology), IGAP (International Genetics of Alzheimer Disease Project (IGAP), ADSP (Alzheimer Disease Sequencing Project) and IGGC (International Genetics of Glaucoma Consortium). Over the years, she served on various scientific committees, including the International Society for Genetic Epidemiology (IGES), the American and European Society for Human Genetics (ASHG, ESHG). She founded the MSc and PhD program in Genetic Epidemiology of the Erasmus University Medical Center of which she is the scientific director. Since 2014, she is a member of the Royal Netherlands Academy of Arts and Sciences.

Positions and Honors

Positions and employment:

2016-now     Full Professor Translational Epidemiology, Faculty Science, Leiden University, TheNetherlands

2001-now     Full professor of Genetic Epidemiology, Department of Epidemiology & Biostatistics, Erasmus University Medical School Rotterdam, The Netherlands

2000-2001    Associate professor and head of Genetic Epidemiology, Department of Epidemiology & Biostatistics, Erasmus University Medical School Rotterdam, The Netherlands

1993-2000    Assistant professor and head of Genetic Epidemiology, Department of Epidemiology & Biostatistics, Erasmus University Medical School Rotterdam, The Netherlands

1992-1993    Postdoctoral Fellow, Department of Neurology, Neurogenetics section, Boston University School of Medicine, USA

1988-1993    PhD Genetic Epidemiology of Alzheimer Disease, Erasmus University, The Netherlands

1987-1988    Research Fellow, Dutch Childhood Leukaemia Study Group, The Hague, The Netherlands

 

Foreign training/appointments:

1995    Department of Genetics, Medical School, Stanford University, USA (Prof Dr N Risch)

1992    Postdoctoral Fellow, Department of Neurology,  Boston University School of Medicine, USA (Dr LA Farrer)

1991    Research fellow, MRC Biostatistics Statistics Unit Cambridge (Dr DG Clayton)

 

Awards:

2014    Member of the Royal Academy of Sciences

2007    Honorable member of Austrian Alzheimer Association

1998    Netherlands Organisation for Scientific Research: Pioneer grant award: Genetics of Alzheimer’s disease

1996    University of Leiden: Herman Boerhaave award for genetic epidemiologic research

1993    Gerontology and Geriatrics Society: Junior research award

1992    Erasmus University Rotterdam: Research award

 

Major collaborations:

  • ADAMS (Alzheimer’s disease, Alcoholism and Schizophrenia)
  • ADSP (US Alzheimer's Disease Sequencing Project)
  • BBMRI (BioMolecular Resources Research Infrastructure)
  • CHANCES (Consortium of Longitudinal Studies of Ageing and Health)
  • CHARGE (Cohorts for Heart & Aging Research in Genome Epidemiology)
  • CMSB (Centre for Medical Systems Biology)
  • CREAM (Consortium for genetic research of myopia)
  • EADB (European Alzheimer Disease Biobank)
  • EAGLE (Early Genetics and Lifecourse Epidemiology)
  • ENGAGE (European Network for Genetic and Genomic Epidemiology)
  • EDSP (European Alzheime’s Disease Sequencing Project)
  • EUROSPAN (European special populations research network)
  • ICBP (International Consortium Genetics Blood pressure)
  • GAP (Global CEO Initiative on Alzheimer’s Disease)
  • Global Lipids (International Consortium Genetics of lipids)
  • IGAP (International Genomics of Alzheimer's Project)
  • IGGS (International Genomics of Glaucoma Project)
  • (N)EUROCJD and PRIONscreen (EU consortia of transmissible encephalopaties)
  • NCHA (Netherlands Consortium  on Health Aging)
  • STREGA: The Strengthening and the Reporting of Genetic Association Studies Initiative
  • In Control - The role of microbiota as drivers of cardiovascular diseases

 

Institutional responsibilities:

2010-2014    Board of the Erasmus MC Graduate school

Since 2010   Scientific director Graduate Programme Clinical and Genetic Epidemiology

Since 1993   Head of the Epidemiology biobanks: Rotterdam Study, GenerationR, Erasmus Rucphen Family Study

Since 1993   Programme director MSc/DSc Programme in Genetic Epidemiology, Netherlands Institute for Health Sciences, The Netherlands

Contributions to Science

Publications and citations:

The applicant has (co-)authored over 998 peer-reviewed papers in international scientific journals, 187 of which were (shared) last-author papers. Her h-index is 126. The total number of citations is over 66.541.

 

Top 10 publications as senior author ([n] = total number of citations):

1.  Aulchenko YS, Ripatti S, Lindqvist I,...van Duijn CM, Peltonen L.(shared last authorship) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009; 41:47-55 [653].

2.  Levy D, Ehret GB, Rice K, …van Duijn CM. Genome-wide association study of blood pressure and hypertension. Nat Genet 2009; 41:677-87 [864].

3.  Seshadri S, Fitzpatrick AL, Ikram MA,...Duijn CM van, Breteler MM (shared last authorship). Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832-40 [718].

4.  Teslovich TT, Musunuru K, Smith AV,… van Duijn CM, Peltonen L (shared last author). Clinical, and Population Relevance of 95 Loci Mapped for Serum Lipid Concentrations. Nature 2010; 466:707-713 [1881].

5.  Ehret GB, Munroe PB, Rice KM,…van Duijn CM, Newton-Cheh C (shared last authorship). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478:103-9 [889].

6.  Jonsson T, Stefansson, H, Steinberg S,…van Duijn CM, Thorsteinsdottir U (shared last author).
K. Variant of TREM2 Associated with the Risk of Alzheimer's Disease. N Engl J Med 2013; 10; 368(2):107-16 [586].

7.  Lambert JC, Ibrahim-Verbaas CA, Harold D,...van Duijn CM, Van Broeckhoven C (shared last author). Alzheimer Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45:1452-8 [632].

8.  van der Lee SJ, Holstege H, Wong TH,…van Duijn CM. PLD3 variants in population studies. Nature. 2015;520:E2-3 [17].

9.  Draisma HH, Pool R, Kobl M,…van Duijn CM, Boomsma DI (share last author). Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nat Commun. 2015;6:7208 [10].

10.       Genome of the Netherlands Consortium.Whole-genome sequence variation, population structure and demographic history of the Dutch population. Nat Genet. 2014 Aug;46(8):818-25 [129].

Research Support

Ongoing grants:

2016    IMI; ADAPTED  (2016-2019)

2015    H2020; Common mechanisms and pathways in Stroke and Alzheimer's disease (2015-2020)

2015    ZonMW; VENI Demirkan (2015-2018)

2015    H2020; CORBEL (2015-2019)

2015    NIH/NEI; Myopia Glaucoma (2015-2017)

2015    NWO; BBMRI 2.0 (2015-2017)

2015    H2020: Personalized PREvention of Chronic Diseases (PRECeDI) (2015-2018)

2015    Janssens Pharmaceutics; IMMEDIAD – and MODELLING AD (2015-2016)

2015    ZonMw; JPND: European Alzheimer Disease Biobank (EADB) (2015-2018)

2014    NIH; Rare variants and NHLBI traits in deeply phenotyped cohorts (2014-2018)

2014    NL Lung foundation; Genes and exposures underlying COPD onset (2014-2016)

2014    NIH; A multi-ethnic study of gene-lifestyle interactions in cardiovascular traits        (2014-2017)

2014    ZonMw; Defining genetic polygenic and environmental risk of Alzheimer disease using multiple powerfull cohorts, foranedon epigenetic and stamcell metabolomics (PERADES). (2014-2016)

2013    Netherlands Heart Foundation; The role of microbiota  as drivers of cardiovascular diseases (IN CONTROL) (2013-2017)

2014    NIH; Alzheimer’s disease sequencing project (ADSP) (2014-2016) 

2012    RIVM; Creutzfeld-Jacob Disease (2012-2016)

2012    IUAP; Interuniversity Attraction poles-Phase VII: international partnership (2012-2017)

 

Applications:

2016    H2020; The microbiome: New AvenueS TO Prevent Alzheimer Disease and Related Pathology  (StopAD) (5 years)

2016    The Jerome Lejeune Foundation: Research on Genetic Intellectual Disabilities in particular Down Syndrome (2 years)

 
 
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