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Ayse Demirkan


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Ayse Demirkan

Phone+31 (0)10 70 43486
Emaila.demirkan@erasmusmc.nl

Biographical Sketch

POSITION TITLE: Postdoctoral Researcher


EDUCATION/TRAINING
Institution and location Degree Completion Date Field of Study
Istanbul University BSc 2002 Biology
Istanbul University Institute for Experimental Medical Research MSc 2006 Human genetics
Netherlands Institute of Health Sciences MSc 2008 Genetic Epidemiology
Erasmus University Medical Center PhD 2012 Genetic Epidemiology

Personal Statement

I am a postdoctoral researcher in the Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC Rotterdam, the Netherlands. My research combines biology with epidemiology to identify disease related metabolites, their genetic determinants and responsible pathways, integrating different levels of human data. In the last 5 years I searched for genetic variants which increase depression risk, through leading genetic association based (CHARGE Consortium.) and linkage based studies (ERF) and showed the polygenic architecture for depressive symptoms and lipids. I also focused on phospholipid markers as potential circulating markers for depression. I have lead and contributes to several genetic association studies (inter)nationally (EUROSPAN C., BBMRI-NL-RP4, MAGNETICS, CHARGE, ENGEAGE) uncovering novel genetic loci controlling human metabolism. Currently I supervise and coordinate the metabolomics research in complex phenotypes (blood pressure, cardiovascular disease, Alzheimer Disease, longevity, migraine, depression) in the Genetic Epidemiology Unit, Erasmus MC, in. In last two years I particularly focus on T2DM. I exploit the consanguinity in ERF population and its impact on individuals’ metabolic phenotype leading to T2DM, and I search for causal biological pathways through researching the T2DM related metabolites. Meanwhile I started to focus on the related environmental players, starting from anti-diabetic and statin medication, as well as gene x medication interactions, but also the functional units: RNA and protein regulators of metabolites in related to T2DM.

Positions and Honors

Positions and employment:
2015-present: Postdoctoral Researcher, Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, the Netherlands.
2013-2015: Postdoctoral Researcher, LUMC, the Netherlands.
2008-2012: PhD researcher Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, the Netherlands.

Contributions to Science

In 2012, I was one of the pioneers to combine the fields of genetics and metabolomics to gain deeper understanding of human metabolism with help of genome-wide association studies. The resulting work yielded the following papers, in collaboration with international groups:
Demirkan et al. Plos Genetics 2012
Demirkan et al. Plos Genetics 2015
Draisma et al. Nature Comm. 2015
Kettunen et al. Nature Comm. 2016

Research Support

Current grant: Veni by NOW (2015) “Beyond genome-wide association studies: Dissecting the familial component of recessive genetic disease”, 224K Euros

 
 
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