Contributions to Science
1. I have investigated the role of dietary fatty acids in cardiometabolic health, as well the role of fatty acids in cancer. I have shown that n-6 polyunsaturated fatty acids, contrary to common beliefs, may reduce inflammation. Also, I have shown that different sources of n-3 polyunsaturated fatty acids might have different effects on cardiometabolic health and cancer. Furthermore, I have shown a complex interaction between dietary fatty acids, serum total cholesterol and fiber intake.
a. Muka et al. J Epidemiol Community Health 2016
b. Kraja et al. J Nutr 2015
c. Muka et al. Am J Epi 2015
d. Muka et al. Clinic Nutr 2016
2. In 2015-2016, I have published several systematic reviews and original data analysis examining the role of estrogen receptor beta, sex hormones and vasomotor symptoms in the risk of developing cardiometabolic outcomes, such as cardiovascular disease and diabetes. Subsequently, I have recently shown that age of menopause may be a marker of cardiovascular disease and mortality in postmenopausal women. Furthermore, in a large meta-analysis of randomized controlled trials, I have shown that phytoestrogen supplementations may reduce menopausal symptoms, common symptoms during menopause. Further research, should work whether use of phytoestrogen can reduce also the risk of cardiovascular disease in women.
- Muka et al. JAMA Cardiol 2016
- Franco et al. JAMA 2016
- Muka et al. Plos One 2016
- Daan NM et al. J Clin Endocrinol Metab. 2016
- Jaspers et al. J Clin Endocrinol Metab 2016
- Muka et al. Maturitas 2016
- Franco et al. Maturitas 2015
3. In 2015, I focused on identifying determinants of age at menopause. In a meta-analysis we found that alcohol intake is associated with late menopause. I am working further on this research line and trying to identify other modifiable factors that may lead to menopause onset.
a. Taner et al. Hum Reprod Update 2066