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Daniel Bos



Daniel Bos

Phone+31 10 704 37 91

Biographical Sketch

POSITION TITLE: Postdoctoral scientist in Radiology and Epidemiology

Institution and location Degree Completion Date Field of Study
Erasmus University Medical Center MD 2009 Medicine
Netherlands Institute for Health Sciences MSc 2012 Health Sciences
Erasmus University Medical Center PhD 2013 Radiology and Epidemiology

Personal Statement

Currently I hold a position as a postdoctoral scientist in the departments of Radiology and Epidemiology of the Erasmus MC Rotterdam, the Netherlands. My research focuses on the interface of cardiovascular and neurodegenerative diseases, with a strong emphasis on imaging. Specifically, I aim to obtain relevant biomarkers for improved understanding and prediction of these diseases, and to identify potential targets for intervention strategies. Against this background, I have gained broad experience in the application and acquisition of multi-modal imaging on the population-level, and performed important pioneering-work on the identification and quantification of specific imaging-based biomarkers of vascular disease. Specifically, my work on intracranial carotid artery calcification as important risk factor for stroke and dementia has had considerable impact, and has also led to an extension of my research horizon towards clinical studies on the value of carotid artery calcification in stroke patients. The multidisciplinary aspect of my research allowed me to establish close collaborations with the departments of Biomedical Engineering, Cardiology and Neurology within the Erasmus MC during the past years. I have also extended my collaborations outside of the Erasmus MC to the University of Valladolid (Prof. Arenillas), the AsIA-Barcelona Study in Spain (Prof. Davalos), the Universidade Federal de Minas Gerais (Prof. Barreto), and the Harvard T.H. Chan School of Public Health (Prof. Hofman), which allow a wide utilization of my research. During the past years I was awarded the Best Scientific Paper Award of the Dutch Society of Radiology (2011), and the Van Leersum fellowship of the Royal Netherlands Academy of Arts and Science (2015). I currently lead a research team consisting of 1 PhD-student, 1 research staff and 5 MSc-students.

Positions and Honors

Positions and employment:
2014-present: Postdoctoral scientist, Depts. of Radiology and Epidemiology, Erasmus MC, the Netherlands.
2014-present: Imaging Coordinator for European Population Imaging Infrastructure, Dept. of Radiology, Erasmus MC, the Netherlands.
2016: Visiting scientist, Dept. of Epidemiology, Harvard T.H. Chan School of Public Health, United States of America.
2013-2014: Resident in Radiology, Dept. of Radiology, Erasmus MC, the Netherlands.
2010-2013: PhD-candidate, Depts. of Radiology and Epidemiology, Erasmus MC, the Netherlands.
2011: General physician, Het Doktershuis Ridderkerk, the Netherlands.

2015: Van Leersum fellowship of the Royal Netherlands Academy of Arts and Science.
2011: NVvR Best Scientific Paper Award of the Dutch Society of Radiology.
2009: Awarded MD-degree cum laude.

Contributions to Science

1. Intracranial arteriosclerotic disease
During the last decade, intracranial arteriosclerosis as a cause of stroke and dementia has received increasing interest, particularly in populations from Asian and African descent. During the last 5 years, I have expanded this research also to the white population and showed that also in whites, intracranial arteriosclerosis is the most important risk factor for stroke, and contributes considerably to the development of neurodegenerative diseases, such as dementia. My work on this topic has fueled novel studies on the further investigation of intracranial arteriosclerosis, which as a research field will likely grow rapidly during the coming years.
Relevant papers:
• Bos D, et al. Intracranial carotid artery atherosclerosis; prevalence and risk factors in the general population. Stroke. 2012; 43:1878-84.
• Bos D, et al. Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study. JAMA Neurol. 2014; 71:405-11.
• Bos D, et al. Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality: The Rotterdam Study. Circ Cardiovasc Imaging. 2015. DOI:10.1161/CIRCIMAGING.115.003843

2. Vascular disease and neurodegeneration
In line with my research on intracranial arteriosclerotic disease, I also investigated the role of vascular disease at other locations in the vascular system. This is very important, and I have shown that although manifestations of atherosclerosis may be present systemically throughout the arterial system, the degree of atherosclerosis within individuals varies across vessel beds. This directly related to site-specific differences in the etiology of atherosclerosis, and a differential risk of subsequent disease. In particular, I investigated the role of vascular disease in different vessel beds and the development of neurodegenerative brain disease.
Relevant papers:
• Bos D, et al. Calcification in major vessel beds relates to vascular brain disease. Arterioscler Thromb Vasc Biol. 2011; 31:2331-37.
• Bos D, et al. Atherosclerotic calcification relates to cognitive function and brain changes on MRI. Alzheimers Dement. 2012; 8 :S104-11.
• Bos D, et al. Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline. Alzheimers Dement. 2015; 11(6):639-47.e1.
• Van den Bouwhuijsen, et al. Coexistence of Calcification, Intraplaque Hemorrhage and Lipid Core within the Asymptomatic Atherosclerotic Carotid Plaque: The Rotterdam Study. Cerebrovasc Dis. 2015; 39(5-6):319-24.

3. Emerging biomarkers of vascular risk
In addition to vascular calcification as markers of arteriosclerosis, there has been rapidly increasing interest in the identification of (imaging-based) biomarkers of vascular disease in an earlier stage of the disease. Although for many of these the clinical value should still be established, pioneering work in which I prominently participated has already delivered several potentially interesting markers, such as the amount of epicardial fat, and the amount of liverfat.
Relevant papers:
• Shahzad R, et al. Automatic quantification of epicardial fat volume on non-enhanced cardiac CT scans using a multi-atlas segmentation approach. Med Phys. 2013; 40:091910.
• Bos D, et al. Epicardial fat volume is related to atherosclerotic calcification in multiple vessel beds. Eur Heart J Cardiovasc Imaging. 2015; 16:1264-1269.
• Bos D, et al. Liver fat is related to cardiovascular risk factors and subclinical vascular disease: the Rotterdam Study. Eur Heart J Cardiovasc Imaging. 2016. In press.

Research Support

2016: Fellowship Harvard T.H. Chan School of Public Health
2016: Alzheimer Nederland Travel Fellowship
2016: Alzheimer Nederland Personal International Research Fund
2015: Van Leersum Grant of the Royal Netherlands Academy of Arts and Sciences
2013: Alzheimer Nederland Research Fund
2011: Alzheimer’s Association Travel Fellowship
2011: Trustfonds Travel Grant

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