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Daniel Bos


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Daniel Bos

Phone+31 10 704 37 91
Emaild.bos@erasmusmc.nl

Biographical Sketch

POSITION TITLE: Assistant Professor in Radiology and Epidemiology


EDUCATION/TRAINING

Institution and location Degree Completion Date Field of Study
Erasmus University Medical Center MD 2009 Medicine
Netherlands Institute for Health Sciences MSc 2012 Health Sciences
Erasmus University Medical Center PhD 2013 Radiology and Epidemiology

Personal Statement

Currently I hold a position as an Assistant Professor in the department of Radiology and Nuclear Medicine and the department of Epidemiology of the Erasmus MC Rotterdam, the Netherlands. My research focuses on the interface of cardiovascular and neurodegenerative diseases, with a strong emphasis on imaging. Specifically, I aim to obtain relevant biomarkers for improved understanding and prediction of these diseases, and to identify potential targets for intervention strategies. During the years, I have set out two main research lines. One of these is focused on the causes and consequences of intracranial arteriosclerosis. In this field, I performed important pioneering-work on the identification and quantification of intracranial carotid artery calcification as one the most important risk factors for clinical stroke and as important contributor to dementia. This work has had considerable impact and has also led to an extension of my research horizon towards clinical studies on the value of carotid artery calcification in stroke patients. My other research line revolves around the early detection of cardiovascular disease, by maximally leveraging existing medical imaging examinations.

The multidisciplinary aspect of my research allowed me to establish close collaborations with the departments of Biomedical Engineering, Cardiology, and Neurology within the Erasmus MC. Also outside of Erasmus MC, I collaborate with various renowned institutions including the University of Utrecht , the University of Valladolid, the Universidade Federal de Minas Gerais, and the Harvard T.H. Chan School of Public Health.

During the past years I was awarded the Best Scientific Paper Award of the Dutch Society of Radiology (2011), the Van Leersum fellowship of the Royal Netherlands Academy of Arts and Science (2015), and the Lourens Penning Prize for the best publication in Neuroradiology (2016). I currently lead a research team consisting of 2 PhD-students, and 5 MSc-students.

Positions and Honors

Positions and employment:

2018-present: Assistant Professor, Depts. of Radiology and Epidemiology, Erasmus MC, the Netherlands.
2014-present: Imaging Coordinator for European Population Imaging Infrastructure, Dept. of Radiology, Erasmus MC, the Netherlands.
2014-2018: Postdoctoral scientist, Depts. of Radiology and Epidemiology, Erasmus MC, the Netherlands.

2016-present: Visiting scientist, Dept. of Epidemiology, Harvard T.H. Chan School of Public Health, United States of America.
2013-2014: Resident in Radiology, Dept. of Radiology, Erasmus MC, the Netherlands.
2010-2013: PhD-candidate, Depts. of Radiology and Epidemiology, Erasmus MC, the Netherlands.
2011: General physician, Het Doktershuis Ridderkerk, the Netherlands.

Honors:

2017: Alzheimer Nederland Fellowship.

2016: Lourens Penning Prize of the Dutch Society of Radiology.

2015: Van Leersum fellowship of the Royal Netherlands Academy of Arts and Science.
2011: NVvR Best Scientific Paper Award of the Dutch Society of Radiology.
2009: Awarded MD-degree cum laude.

Contributions to Science

1. Intracranial arteriosclerosis
During the last decade, intracranial arteriosclerosis as a cause of stroke and dementia has received increasing interest, particularly in populations from Asian and African descent. During the last five years, I have expanded this research also to the white population and showed that also in whites, intracranial arteriosclerosis is the most important risk factor for stroke, and contributes considerably to the development of neurodegenerative diseases, such as dementia. Additionally, I have done important research into the etiology of intracranial arteriosclerosis. My work on this topic has fueled novel studies on the further investigation of intracranial arteriosclerosis, which as a research field will likely grow rapidly during the coming years.
Relevant papers:
- Bos D, et al. Stroke. 2012.
- Bos D, et al. JAMA Neurol. 2014.
- Bos D, et al. Circ Cardiovasc Imaging. 2015.

- Adams H, et al. Stroke. 2016

- Bos D, et al. Stroke. 2016

- Vojinovic D, et al. Atherosclerosis. 2017.

- Kockelkoren R, et al. JACC. 2018

 

2. Emerging biomarkers of vascular risk
In addition to vascular calcification as markers of arteriosclerosis, there has been rapidly increasing interest in the identification of (imaging-based) biomarkers of vascular disease in an earlier stage of the disease. Although for many of these the clinical value should still be established, pioneering work in which I prominently participated has already delivered several potentially interesting markers, such as the amount of epicardial fat, and the amount of liver fat.
Relevant papers:
- Shahzad R, et al. Med Phys. 2013.
- Bos D, et al. Eur Heart J Cardiovasc Imaging. 2015.
- Bos D, et al. Eur Heart J Cardiovasc Imaging. 2016.

- Bos D, et al. JACC Cardiovasc Imaging. 2017.

- Bos D, et al. Eur Radiol. 2018.

Research Support

  • BrightFocus Alzheimer Research Grant – (2017-2019) – Role: P.I.
  • Netherlands Brain Foundation 2018-present – Role: co-investigator.
  • Harvard T.H. Chan School of Public Health Fellowship(2016) – Role: P.I.
  • Alzheimer Nederland Personal Fellowship  – Role: P.I.
  • Van Leersum Grant of the Royal Netherlands Academy of Arts and Sciences – (2015-2016) – Role: P.I.

 
 
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