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Vincent Jaddoe, MD, PhD



Vincent Jaddoe, MD, PhD

Phone+31 (0)10 70 43405

Biographical Sketch

POSITION TITLE: Director Generation R Study
Professor of Paediatric Epidemiology, Paediatrician, Principal Investigator Generation R Study (Erasmus MC)
Adjunct Professor of Paediatric Epidemiology (Harvard School of Public Health)


Institution and location Degree Completion Date Field of Study
Leiden University Medical Center MD 09/1999 Medicine
Erasmus University Medical Center PhD 05/2006 Pediatrics
Erasmus University Medical Center Registration as specialist 2009 Pediatrics

Personal Statement

My research is focused on 3 main themes:
- Maternal and fetal health;
- Early fetal and infant programming of common diseases;
- Genetics and epigenetics of common diseases in childhood;
General aim of this research line is to explore how genetic variants and environmental exposures lead to maternal gestational complications, fetal and childhood developmental adaptation mechanisms, and risk factors for common diseases. This life-course research is largely embedded in the Generation R Study, a population-based prospective cohort study among 10,000 pregnant women and their children. Since 2006, he is principal investigator of the Generation R Study, and the related paediatric epidemiology research line at the Departments of Epidemiology and Paediatrics, Erasmus MC. For this research, he established a close collaboration with the departments of Child and Adolescent Psychiatry, Internal Medicine, Public Health, and Obstetrics and Gynaecology. His research is conducted in close collaboration with several international research groups. Genetic association studies are embedded in the EGG Consortium and EAGLE Consortium in which various birth cohorts (>30,000 subjects) combine their genome wide association studies efforts. He is also principal investigator in four EU Framework-7 funded research programmes (CHICOS, EARLY NUTRITION, EUCCONET, GEOCODE).

Positions and Honors

I. Positions and employment:
1999-2006: PhD student, Dept. of Epidemiology, Dept. of Paediatrics, Erasmus University Rotterdam, NL
2007-2011: Assistant Professor Paediatric Epidemiology (0.2 0.5 fte) Dept. of Epidemiology, Dept. of Paediatrics, Erasmus University Rotterdam, NL
2009-2010 : Visiting Research Fellow, Dept. of Nutrition, Harvard School of Public Health, Harvard University, USA
2011-2013: Associate Professor Paediatric Epidemiology, Dept. of Epidemiology, Dept. of Paediatrics, Erasmus University Medical Center, Rotterdam, NL
2013-present: Professor of Paediatric Epidemiology, Paediatrician, Principal Investigator Generation R Study, Dept. of Epidemiology, Dept. of Paediatrics Erasmus University Medical Center, Rotterdam, NL
2013-present: Adjunct Professor of Paediatric Epidemiology, Dept. of Epidemiology, Harvard School of Public Health. Harvard University, Boston MA, USA.

Clinical work
01/03/2003 - 01/09/2009: Residency in Paediatrics, Erasmus University Medical Center - Sophia Childrens Hospital, Rotterdam, NL

II. Other relevant experience and professional memberships:
PhD External Reviewing Committees
* Member Thesis Defense Committee of 8 PhD students in the Netherlands and France Scientific Advisory Boards
* ILSE The Effects of Pre- and Postnatal Nutrition of Infants with Obese Mothers; Metabolic Imprinting and Later Health Outcomes, Brussels, Belgium, 2009
* Klaar een kind, Rotterdam, 2010-2013 (Advisory board)
* ZonMw Programme: Pregnancy and childbirth, Netherlands Organisation of Health Research and Development, 2011 onwards
* OCW: Zwaartekracht. Individual Development, 2014 onwards (Scientific Advisory Board)
* Youth Health Council (Jonge Gezondheidsraad) 2013 onwards
Congress Committees
* Society for Longitudinal and Life Course Studies (SLLS) Scientific Committee, Paris, France 2012, 2013 (Review committee)
* Developmental Origins of Origins of Health and Disease (DOHaD) Congress 2012, Rotterdam, The Netherlands, 2012 (Chair Organizing and review committees)
* American Diabetes Association, 73rd Scientific Sessions, Chicago, Il 2013 (Review committee)
* World Congress Developmental Origins of Origins of Health and Disease (DOHaD), Rotterdam, The Netherlands, 2012 (Chair Organizing and review committees)
* PLOS ONE (from 2011-2015)
* Eur J Epidemiol (from 2012 onwards)
Professional society and/or committee
* Nederlandse Vereniging van Kindergeneeskunde (from 2003 onwards)
* Developmental Origins of Health and Disease (DOHaD) Society (from 2012 onwards)
* Society of Paediatric and Perinatal Epidemiologic Research (SPER) (from 2013 onwards)

III. Honors and awards
2000: Scholarship Ter Meulen Fonds: Research fellowship Medical Research Council, Epidemiology Resource Center, University of Southampton;
2005: Netherlands Institute of Health Sciences Award for best scientific article: Maternal smoking in pregnancy and blood pressure in the offspring: a 27 years follow-up study;
2007: Erasmus University Rotterdam Young Researchers Award 2007
2008: 3rd Young Investigators Award Dutch Society of Paediatrics

Contributions to Science

I. My ten most contributing (most significant) publications":
1. Verburg BO, Jaddoe VW, Wladimiroff JW, Hofman A, Witteman JC, Steegers EA (2008). Fetal hemodynamic adaptive changes related to intrauterine growth: the Generation R Study. Circulation 117:649-59.
2. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Eriksson JG, Peltonen L, Mohlke KL, Grant SF, Hakonarson H, Koppelman GH, Dedoussis GV, Heinrich J, Gillman MW, Palmer LJ, Frayling TM, Boomsma DI, Davey Smith G, Power C, Jaddoe VW, Jarvelin MR, Early Growth Genetics C, McCarthy MI (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 42:430-5. (starred senior author)
3. Mook-Kanamori DO, Steegers EA, Eilers PH, Raat H, Hofman A, Jaddoe VW (2010) Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA 303:527-34.
4. Gaillard R, Bakker R, Steegers EAP, Hofman A, Jaddoe VW (2011) Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders. The Generation R Study. Eur Heart J 32:3088-97.
5. Heppe DH, van Dam RM, Willemsen SP, den Breeijen H, Raat H, Hofman A, Steegers EA, Jaddoe VW (2011) Maternal milk consumption, fetal growth and the risks of neonatal complications. The Generation R Study. Am J Clin Nutr 94:501-9.
6. Bradfield JP, Taal HR, Timpson NJ, Scherag A, Gilliland FD, Heinrich J, Wheeler E, Barroso I, O'Rahilly S, Meirhaeghe A, Sorensen TI, Power C, Palmer LJ, Hinney A, Widen E, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF (2012) A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet 44:526-31.
7. Sonnenschein-van der Voort AM, Jaddoe VW, Raat H, Moll HA, Hofman A, de Jongste JC, Duijts L (2012) Fetal and infant growth and asthma symptoms in preschool children: the Generation R Study. Am J Respir Crit Care Med 185: 731-7.
8. Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet 44:532-8. (starred senior author)
9. Jaddoe VW, de Jonge LL, Hofman A, Franco OH, Steegers EA, Gaillard R (2014) First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study. BMJ 348:g14.
10. Jaddoe VW, de Jonge LL, van Dam RM, Willett WC, Harris H, Stampfer MJ, Hu FB, Michels KB (2014) Fetal exposure to parental smoking and the risk of type 2 diabetes in adult women. Diabetes Care 37:2966-73.

II. Median impact factor for my research field(s):
Pediatrics; 1.465

III. The top 3 leading Journals in my research field:
1. International Journal of Epidemiology; 2. Pediatrics; 3. Circulation

Research Support

Grants PI Amount Year Status
HORIZON2020, LIFECYCLE Consortium (coordinator) 9.800k 2016 Ongoing
Childhood abdominal adiposity; Danone 330k 2015 Ongoing
European Research Council Consolidator Grant. Embryo and later health. ERC. 1.960k 2014 Ongoing
VIDI: Fetal plasticity and health in later life. A life course study on focused on epigenetic, metabolic and vascular programming; Netherlands Organization of Scientific Research 800k 2013 Ongoing
Developmental origins of childhood asthma; Asthma foundation 250k 2012 Completed
MR Imaging in children from Rotterdam; Laurens Stichting 330k 2012 Completed
MRI Studies in Generation R; Stichting bevordering Volkskracht 412k 2011 Completed
Early origins of abdominal adiposity; Danone 240k 2010 Completed
VENI: Genetics variants related to fetal growth and type 2 diabetes; Netherlands Organization of Scientific Research 250k 2009 Completed
Generation R Foucs at 5; Shell Nederland 100k 2009 Completed
Generation R Focus at 5; Stichting bevordering Volkskracht 450k 2009 Completed
Generation R Biobank; Trust Foundation Erasmus University 120k 2008 Completed
Fetal origins of impaired renal function and high blood pressure; Dutch Kidney Foundation 250k 2008 Completed
Influences of fetal growth, blood flow patterns and their determinants on vascular and cardiac function at the age of 5 years; Dutch Heart Foundation 250k 2008 Completed
Subtotal 5.742k
Grants Co-PI Amount Year Status
Dynahealth. Horizon2020 (for Erasmus MC) 720k 2015 Ongoing
Phthalates, BPA, Trajectories of In and Ex Utero Growth and Cardiometabolic Risks NIH, 2014 (for Erasmus MC) 550k 2014 Ongoing
Novel Epigenomic Biomarker of Prenatal Risk Factors, and Childhood Obesity; NIH, 2013 ( for Erasmus MC) 105k 2013 Ongoing
Early Nutrition; EU-FP7 Grant (for Erasmus MC) 180k 2012 Completed
CHICOS (Child Cohorts Studies in Europe); EU-FP7 Grant (for Erasmus MC) 330k 2011 Completed
Subtotal 1.985k

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