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Najaf Amin



Najaf Amin


Biographical Sketch

POSITION TITLE: Postdoctoral Scientific Researcher


Institution and location Degree Completion Date Field of Study
Quaid-e-Azam University, Islamabad, Pakistan MSc 01/2001 Statistics
Netherlands Institute of Health Sciences DSc 08/2007 Clinical Epidemiology
Erasmus University Medical Center PhD 03/2011 Genetic Epidemiology
Erasmus University Medical Center Postdoc 03/2011-present Genetic epidemiology

Personal Statement

I received my PhD degree in Genetic Epidemiology in 2011 and currently working as a Post doc researcher at the department of Epidemiology, Erasmus university medical center, Rotterdam. My PhD thesis focused on discovery of genes associated with various behavioral traits including Attention Deficit Hyperactivity Disorder, sleep, personality and addiction. Now my primary focus is on uncovering the genetics of complex psychiatric and neurological traits/diseases in both population and family based studies. The current focus is on discovering rare genetic sequence variation affecting depression using segregation, association, single variant and gene-based testing of exome/whole genome sequence and chip data and translating these discoveries into therapeutical targets. I lead statistical and bioinformatics analyses of various kinds of genomic data including array, imputed and whole genome/exome sequence. My expertise is the application of a wide range of statistical and bio-informatics methodologies on genomic datasets. I teach these analyses and methods in the genetic epidemiology courses offered by the Netherlands Institute of Health Sciences. During the 4 years as a post doc I have co-promoted two PhD theses and supervised six MSc theses. Currently I am supervising 6 PhD students and three MSc students. I have over 165 publications in various peer-reviewed international journals (H-index = 49).

Positions and Honors

2011: Postdoctoral Fellow, Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
2007: PhD Student, Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical School Rotterdam, The Netherlands.
2005: Research Fellow, Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical School Rotterdam, The Netherlands.
2001-2005: Lecturer in Statistics, Islamabad, Pakistan

• Indigenous scholarship for MS leading toward PhD (4 years), Higher Education Commission of Pakistan 2004
• Overseas scholarship for MS leading towards PhD in the Netherlands (4 years), Higher Education Commission of Pakistan 2005
• Personal Grant from the Netherlands Brain Foundation 2013 (€150,000)

Contributions to Science

Total 165 publications as a co-author. See

First and Last authored:
1. Amin N, van Duijn CM, Aulchenko YS. A genomic background based method for association analysis in related individuals. PLoS One. 2007 Dec 5;2(12):e1274.
2. Amin N, Aulchenko YS, Dekker MC, Ferdinand RF, van Spreeken A, et al. Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population. Eur J Hum Genet. 2009 Jul;17(7):958-66.
3. Amin N, van Duijn CM, Janssens AC. Genetic scoring analysis: a way forward in genome wide association studies? Eur J Epidemiol. 2009;24(10):585-7.
4. Amin N, Schuur M, Gusareva ES, Isaacs A, Aulchenko YS, et al. A genome-wide linkage study of individuals with high scores on NEO personality traits. Mol Psychiatry. 2012 Oct;17(10):1031-41. 5. Amin N, Byrne E, Johnson J, Chenevix-Trench G, et al. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2012 Nov;17(11):1116-29.
6. Amin N, Hottenga JJ, Hansell NK, Janssens AC, et al. Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. Eur J Hum Genet. 2013 Aug;21(8):876-82.
7. Vojinovic D, Adams HH, van der Lee SJ, Ibrahim-Verbaas CA, Brouwer R, van den Hout MC, Oole E, van Rooij J, Uitterlinden A, Hofman A, van IJcken WF, Aartsma-Rus A, van Ommen GB, Ikram MA, van Duijn CM, Amin N. The dystrophin gene and cognitive function in the general population. Eur J Hum Genet. 2014 Sep 17.
8. Amin, N.; Jovanova, O.; Adams, H. H. H., et al. Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms, Mol Psychiatry. 2016.
9. Amin, N.; Belonogova, N. M.; Jovanova, O., et al. Non-synonymous variation in NKPD1 increases depressive symptoms in the European populations, Biological Psychiatry. Accepted 2016.
10. Amin N, Allebrandt KV, van der Spek A, Müller-Myhsok B, Hek K, et al. Genetic variants in RBFOX3 are associated with sleep latency. Eur J Hum Genet. 2016 May 4.

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